Ex-Capcom and Resident Evil creator Shinji Mikami has said he won't be playing Resident Evil 5 when it arrives because it'll cause him too much stress:
"I probably won't play it. I won't like it, because it's not going to be the game I would have made. It'll just cause me stress if I play it. I think it could be fun for gamers to play it, but not for someone who has developed Resident Evil games. If I see anything in Resident Evil 5 that isn't done well, I'll be angry!"
Mikami also commented on the similarities between Resident Evil 4 and 5 and stated how the sixth version of the game would need to re-invent the series:
"I think Resident Evil 5 doesn't need to change the series, but Resident Evil 6 will have to reinvent the series with another full model change or else it won't be able to keep on going."
Mikami has since let Capcom hence why he's not working on Resident Evil 5, and is currently working on joint Suda 51 horror game with EA and an unannounced game for Sega.